In response to a conditioning stress, the expression of a set of molecular chaperones called heat shock proteins is increased.In neurons, stress-induced and constitutively expressed molecular chaperones protect against damage induced by ischemia and neurodegenerative diseases, however the molecular basis of this protection is not known.Here we have
Block Compressed Sensing of Images Using Adaptive Granular Reconstruction
In the framework of block Compressed Sensing (CS), the reconstruction algorithm based on the Smoothed Projected Landweber (SPL) iteration can achieve the better rate-distortion performance with a low computational complexity, especially for using the Principle Components Analysis (PCA) to perform the adaptive hard-thresholding shrinkage.However, du
Identification of a chromatin regulator signature and potential candidate drugs for bladder cancer
Abstract Background Bladder cancer (BLCA) is a malignant tumor with a dismay outcome.Increasing evidence has confirmed that chromatin regulators (CRs) are involved in cancer progression.Therefore, we aimed to explore the function and prognostic value of CRs in BLCA patients.Methods Chromatin regulators (CRs) were acquired from the previous top rese
Hs1Cas12a and Ev1Cas12a confer efficient genome editing in plants
Cas12a, also known as Cpf1, is a highly versatile CRISPR-Cas enzyme that has been widely used in genome editing.Unlike its well-known counterpart, Cas9, Cas12a has unique features that make it a highly efficient genome editing tool at AT-rich genomic regions.To enrich the CRISPR-Cas12a plant genome editing toolbox, we explored BLUSH BARE PEACH #120
Polymer brush in articular cartilage lubrication: Nanoscale modelling and simulation
Human knee joints move smoothly under high load conditions due to articular cartilage and synovial fluid.Much attention is paid to the role of proteoglycans.It is suggested that a part of proteoglycan forms aggregate on the cartilage surface, making a polymer brush, which has an important role in lubrication.In order to examine the lubrication mech